This work objective deals with analyses the instrumental rationality of the New Political Economics in the transformation State Institutional concerning a conceptual and methodological transdisciplinary that involve the interaction of political and economics. The rationality analyses since its individual and social components to untie its implications in theory of the collective action and in economics rationality of the decisions, as elements for determine the different political economics focus. Special emphasis concerning the implementation of the institutionalism current principles until mature in the denominated neo institutionalism and just a New Political Economics passing by the tentative failure and imposition of the fundamental premises the New Classic Macroeconomic in the process regulations of the economics globalization. At last, it has been concluded that the New Political Economics proportionate the theorical methodological fundaments and the needed instruments for the processes of the Institutional State change and transformation.
